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Islet Transplantation and Beta Cell Replacement Therapy
- James Shapiro (University of Alberta, Edmonton, Canada)
- James Shaw (The Medical School, Newcastle-Upon-Tyne, UK)
- ISBN
- 9780824728625, 0824728629
- Size
- 6 x 9
- Pages
- 368
- Pub Date
- July 2007
Outlining recent advances in beta cell replacement, this reference explores the impact of islet cell transplantation. Edited by a surgeon and an endocrinologist experienced with this technology, this volume examines the challenges of this procedure (including lack of sufficient donor organs and side effects of immunosuppressive therapy) and the benefits.
This guide examines:
• the role endocrinologist's role in holistic assessment and selection of islet transplant recipients
• factors underlying attrition of islet function over time and a need for enhanced graft monitoring post transplantation
• the future of vivo islet imaging
• clinical islet transplant programs and potential models and pitfalls—including cost effectiveness and sustainable integrated approaches
• clinical outcomes and the future of islet transplantation, including alternative sources of beta cells, new insulin-producing cells from adult tissue, and stem cell banks
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